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thephysician on Instagram: "Malignant Hyperthermia (MH) — Ultra-Short Definition: Life-threatening hypermetabolic reaction to anesthesia in genetically susceptible patients. Triggers: Succinylcholine, volatile anesthetics. Mechanism: RYR1/CACNA1S mutation → uncontrolled Ca²⁺ release → sustained muscle contraction. Early signs: ↑ EtCO₂ (earliest), muscle rigidity, tachycardia, acidosis. Late signs: Hyperthermia, rhabdomyolysis, hyperkalemia → arrhythmias, myoglobinuria. Diagnosis: Clinical; labs
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