Rheumatoid arthritis starts inside the synovial membrane, which is the thin layer that lines each joint. This membrane normally produces a smooth fluid that helps the joint move without friction. In the early stages of rheumatoid arthritis, the immune system mistakenly identifies components of the synovial membrane as harmful. Immune cells such as T cells and macrophages enter the joint and begin releasing inflammatory signals. These signals activate more immune cells and create a cycle of incre
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