Mar 16, 2026 · In this issue of the JCI, Köcher et al. have demonstrated that ERG overexpression in human prostate cancer cells rewired DNA double-strand break repair toward a poly (ADP-ribose) …

Email staff@the-jci.org or call 734-222-6050. To avoid confusion regarding correspondence, inquiries, and decisions, the JCI will typically communicate only with the responsible party/corresponding …

Copyright © 2026 American Society for Clinical Investigation ISSN: 0021-9738 (print), 1558-8238 (online)

The JCI considers research submissions in the following categories [Top of page] Click the category name for formatting instructions; or go to How to submit your manuscript for the first time (new …

Submit a manuscript directly to the JCI through your account on the JCI’s submission website. Follow the instructions to either register for an account or access your existing account. Click the button …

BACKGROUND Gut microbes and their metabolites contribute to the host circulating metabolome and exhibit diurnal variation influenced by sleep-wake cycles and meal timing. Sleep deprivation alters …

Feb 16, 2026 · The science of safety: adverse effects of GLP-1 receptor agonists as glucose-lowering and obesity medications

Feb 16, 2026 · Glucagon-like peptide-1 receptor agonists (GLP-1RAs), established therapies for type 2 diabetes and obesity, are increasingly recognized for their potential in neurodegenerative diseases. …

4 days ago · Torres et al. report that disruption of endoplasmic reticulum–associated degradation (ERAD) in neurons through conditional deletion of the ER membrane protein SEL1L impairs motor …

Jun 1, 2011 · Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies Brian D. Lehmann, 1 Joshua A. Bauer, 1 Xi Chen, 2 Melinda E. …