It’s all change at Prelude Therapeutics. The precision oncology biotech is waving goodbye to its chief medical officer, pausing work on SMARCA2 degraders and selling a licensing option to Incyte. This ...

What's the best PS2 game of all time? For the PS2’s 25th anniversary, we’re looking back at the games that made this console truly iconic. These are the games that pushed the technological and ...

The epidemiology of tumor lysis syndrome is evolving with the introduction of newer therapies. The occurrence of tumor lysis syndrome has become a less predictable but increasingly important aspect of ...

The JAK2 gene mutation discovery led to JAK inhibitors, transforming myelofibrosis treatment by targeting the JAK-STAT pathway. Four FDA-approved JAK inhibitors for myelofibrosis include Jakafi, ...

Patients with MPNs are at increased risk for nonthrombotic conditions, including heart failure and pulmonary hypertension, necessitating improved understanding and management strategies. Pulmonary ...

In 1980, Ludwig and colleagues described the histologic features of a newly identified chronic liver condition referred to as nonalcoholic steatohepatitis (NASH) and noted that the majority of the ...

Ischemic stroke is a major cause of death and disability, caused by a sudden loss of oxygen supply to the brain due to blocked blood vessels. Recanalization treatments such as intravenous thrombolysis ...

Panelists discuss how the pathophysiology of pulmonary arterial hypertension involves complex mechanisms across multiple genetic and treatment pathways, with over 20 identified genes and four major ...

During a live event, Karen Seiter, MD, discussed the role of the JAK/STAT pathway in myeloproliferative neoplasms and the use of ruxolitinib to treat myelofibrosis. Seiter: The latest classification ...

Jose is a passionate writer and a video game enthusiast from Argentina. Throughout his career, he has contributed to various entertainment platforms, including the prominent Spanish channel Plano de ...

Anthony is a writer who's worked in the games industry for four years. He's a competitive gamer with a soft spot for retro titles. Anthony enjoys speedrunning a few titles, but Simpson's Hit & Run is ...

Janus kinase inhibitors (JAKis) are an important treatment option for people with chronic inflammatory diseases such as rheumatoid arthritis, psoriasis, Crohn's disease or ulcerative colitis. Since ...