Abstract: Epistasis detection is vital to determining disease susceptibility in the human genome. With rapid advances in technology, multifactor dimensionality reduction (MDR) has become an effective ...

QuadKAST extends the FastKAST software by incorporating quadratic families, enhancing its functionality. Building on the scalability advantages of FastKAST, QuadKAST introduces robust support for ...

I used the IIIVmrMLM to analyis the epistasis loci, but there were an errors as follows: "Epistasis analysis for yield begins" Error in SetMatrixElements(x@address ...

Multiple mutations often have non-additive (epistatic) phenotypic effects. Epistasis is of fundamental biological relevance but is not well understood mechanistically. Adaptive evolution, i.e., the ...

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, has undergone genomic mutations, which have led to the ...

Mutations can work together to make a virus more fearsome, but they can also cancel one another out. This phenomenon, called epistasis, is why scientists are reluctant to speculate on Omicron. By ...

The COVID-19 pandemic is a worldwide public health emergency caused by the β-coronavirus SARS-CoV-2. A very large and continuously increasing number of high-quality whole-genome sequences are ...

Epistasis describes how gene‐gene interactions affect phenotypes, and could have a profound impact on human diseases such as coronary artery disease (CAD). The goal of this study was to identify ...

Genome-wide association studies (GWAS) have been conducted widely to interrogate the genetic architecture of common and complex diseases (McCarthy et al., 2008). For Crohn's disease (CD) and ...

The COL4A1/COL4A2 locus on chromosome 13q34 was significantly associated with coronary artery disease (CAD) in the CARDIoGRAM (Nature Genetics, 2011) and the CARDIoGRAMPlusC4D (Nature Genetics, 2013) ...